Article
Dendritic cell involvement in pulmonary granuloma formation elicited by bacillus calmette-guérin in rats.
American journal of respiratory and critical care medicine - 15 Jun 2002
Tsuchiya Tomoyoshi, Chida Kingo, Suda Takafumi, Schneeberger Eveline E, Nakamura Hirotoshi
Abstract excerpt
Dendritic cells (DCs) are the most potent antigen-presenting cells that play a central role in initiating the primary immune response. However, their role in granulomatous inflammation has not been well studied. The aim of the present study was to elucidate the role of DCs in granuloma formation. Using a rat model of bacillus Calmette-Guérin (BCG)-elicited pulmonary granulomas, we investigated the distribution of...
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