Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations.

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Article

Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations.

The Journal of comparative neurology - 22 Mar 1999

McMenamin P G

Abstract excerpt

Dendritic cells (DC) are regarded as the 'sentinels' of the immune system. They play a crucial role in surveillance of peripheral tissues, trapping antigens encountered there, and migrating via the lymphatics to lymphoid organs where they interact with naive T cells thus generating antigen-specific primary immune responses. Until now it has been assumed DC are largely absent from the brain, meninges, and the...

Topics

Animals
Arachnoid
Choroid Plexus
Dendritic Cells
Dura Mater
Female
Histological Techniques
Immunohistochemistry
Macrophages
Meninges
Phenotype
Pia Mater
Rats
Rats, Inbred Lew

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Open in PubMed

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PMID: 10098945

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