Article
Predicting the functional consequences of genetic variants in co-stimulatory ligand B7-1 using in-silico approaches.
Human immunology - 1 Feb 2021
Mathur Riya, Sharma Loveena, Dhabhai Bhanupriya, Menon Athira M, Sharma Amit, Sharma Narendra Kumar, Dakal Tikam Chand
Abstract excerpt
The purpose of this research is to identify and characterize deleterious genetic variants in the co-stimulatory ligand B7-1, also known as the human cluster of differentiation CD80 marker. The B7-1 ligand and the major histocompatibility complex class II (MHC II) molecules are the main determinants that provide B-cells the required competency to act as antigen presenting cells. For this, participation of both MHC...
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