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Reduced microvascular flow-mediated dilation in Syrian hamsters lacking δ-sarcoglycan is caused by increased oxidative stress.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2025

Richard Alexis, Bocquet Arnaud, Belin de Chantemèle Eric, Retailleau Kevin, Toutain Bertrand, Mongue-Din Héloïse, Guihot Anne-Laure, Fassot Céline, Fromes Yves, Henrion Daniel, Loufrani Laurent

Abstract excerpt

δ-Sarcoglycan mutation reduces mechanotransduction and induces dilated cardiomyopathy with aging. We hypothesized that in young hamsters with δ-sarcoglycan mutation, which do not show cardiomyopathy, flow mechanotransduction might be affected in resistance arteries as the control of local blood flow. Flow-mediated dilation (FMD) was measured in isolated mesenteric resistance arteries, using 3-mo-old hamsters...

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Mechanotransduction, Cellular
Mesocricetus
Nitric Oxide Synthase Type II
Regional Blood Flow

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vasodilator Agents

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PMID: 39485294
DOI: 10.1152/ajpheart.00569.2024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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