Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging.

Physiological genomics - 12 Mar 2004

Csiszar Anna, Ungvari Zoltan, Koller Akos, Edwards John G, Kaley Gabor

Abstract excerpt

Previously we demonstrated that aging in coronary arteries is associated with proinflammatory phenotypic changes and decreased NO bioavailability, which, we hypothesized, promotes vascular disease by enhancing endothelial apoptosis. To test this hypothesis we characterized proapoptotic alterations in the phenotype of coronary arteries of aged (26 mo old) and young (3 mo old) F344 rats. DNA fragmentation analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to ADAM17 Protein
Share to Coronary Vessels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to Endothelium, Vascular

Share to In Situ Nick-End Labeling

Share to Metalloendopeptidases

Share to Rats, Inbred F344

Source

Identifiers

PMID: 15020720
DOI: 10.1152/physiolgenomics.00136.2003

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging.PMID 15020720Read ↗

Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function.Semantic proximity Read ↗

Development of progressive aortic vasculopathy in a rat model of agingSemantic proximity Read ↗

Regulation of Coronary Endothelial Function by Interactions between TNF-α, LOX-1 and Adiponectin in Apolipoprotein E Knockout Mice.Semantic proximity Read ↗

Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies.Semantic proximity Read ↗

Vascular aging in the longest-living rodent, the naked mole rat.Semantic proximity Read ↗

Involvement of Senescence and Mitochondrial Fission in Endothelial Cell Pro-Inflammatory Phenotype Induced by Angiotensin II.Semantic proximity Read ↗

Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humansSemantic proximity Read ↗

Apoptosis in the vascular wall and atherosclerosisSemantic proximity Read ↗

Angiotensin II induces phenotype-dependent apoptosis in vascular smooth muscle cells.Semantic proximity Read ↗

Age-induced reduction in mitochondrial manganese superoxide dismutase activity and tolerance of macrophages against apoptosis induced by oxidized low density lipoprotein.Semantic proximity Read ↗

Apoptosis is involved in the senescence of endothelial cells induced by angiotensin IISemantic proximity Read ↗

Effect of the Antioxidant Lipoic Acid in Aortic Phenotype in a Marfan Syndrome Mouse Model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.