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Article

Kininogen deficiency modulates chronic intestinal inflammation in genetically susceptible rats.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2002

Isordia-Salas Irma, Pixley Robin A, Li Fengling, Sainz Irma, Sartor R Balfour, Adam Albert, Colman Robert W

Abstract excerpt

Genetically susceptible Lewis rats injected in the intestinal wall with peptidoglycan-polysaccharide (PG-APS) polymers develop chronic granulomatous enterocolitis concomitant with activation of the kallikrein-kinin system. To elucidate the role of high-molecular-weight kininogen (HK) in chronic enterocolitis, we back crossed Brown-Norway rats having a HK deficiency with Lewis rats for five generations. Two new...

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Identifiers

PMID: 12065305
DOI: 10.1152/ajpgi.00514.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Kininogen deficiency modulates chronic intestinal inflammation in genetically susceptible rats.PMID 12065305Read ↗

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