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Article

Low endogenous prostaglandin E2 predisposes to relapsing inflammation in experimental rat enterocolitis.

Digestive diseases and sciences - 1 Nov 2000

Kandil H M, Argenzio R A, Sartor R B

Abstract excerpt

Intramural injection of peptidoglycan-polysaccharide (PG-PS) induces acute enterocolitis that spontaneously relapses in Lewis but not Fischer rats. Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) induce prostaglandin E2 (PGE2) secretion, which inhibits secretion of these cytokines by macrophages, suggesting an inhibitory feedback mechanism. We postulate that Lewis rat susceptibility to relapse is...

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Identifiers

PMID: 11215721
DOI: 10.1023/a:1026675005554

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MPO
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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