Article
The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation.
Blood - 15 Oct 2003
Isordia-Salas Irma, Pixley Robin A, Parekh Hemant, Kunapuli Satya P, Li Fengling, Stadnicki Anthony, Lin Yingzhang, Sartor R Balfour, Colman Robert W
Abstract excerpt
Crohn disease is immunologically mediated and characterized by intestinal and systemic chronic inflammation. In a rat model, injection of peptidoglycan-polysaccharide complexes into the intestinal wall induced chronic inflammation in Lewis but neither Fischer nor Buffalo rats, indicating a differential genetic susceptibility. Proteolysis of plasma high molecular weight kininogen (HK) yielding bradykinin and...
Topics
- Animals
- Bradykinin
- CHO Cells
- Cricetinae
- DNA Restriction Enzymes
- Dextran Sulfate
- Escherichia coli
- Glycosylation
- Inflammation
- Kaolin
- Kininogens
- Mutation
- Peptidoglycan