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Article

Chronic intestinal inflammation and angiogenesis in genetically susceptible rats is modulated by kininogen deficiency.

International immunopharmacology - 1 Dec 2002

Isordia-Salas Irma, Pixley Robin A, Li Fengling, Sainz Irma, Balfour Sartor R, Adam Albert, Colman Robert W

Abstract excerpt

Genetically susceptible Lewis rats injected in the intestinal wall with peptidoglycan-polysaccharide (PG-APS) polymers develop chronic granulomatous enterocolitis associated with activation of the kallikrein-kinin system. To elucidate the role of high-molecular-weight kininogen (HK), we backcrossed Brown Norway rats having an HK deficiency with Lewis rats for five generations. Two new strains were produced,...

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PMID: 12489803
DOI: 10.1016/s1567-5769(02)00183-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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