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Article

The RB protein family in retinal development and retinoblastoma: new insights from new mouse models.

Developmental neuroscience - 1 Jan 2004

Bremner Rod, Chen Danian, Pacal Marek, Livne-Bar Izhar, Agochiya Mahima

Abstract excerpt

The Rb gene was isolated almost 20 years ago, but fundamental questions regarding its role in retinal development and retinoblastoma remain. What is the normal function of RB protein in retinogenesis? What is the cell-of-origin of retinoblastoma? Why do retinoblastoma tumors have recurrent genetic lesions other than Rb inactivation? Why is retinoblastoma not induced by defects in cell cycle regulators other than...

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Identifiers

PMID: 15855771
DOI: 10.1159/000082284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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