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Article

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos.

Genes & development - 15 Feb 2001

Ziebold U, Reza T, Caron A, Lees J A

Abstract excerpt

The E2F transcription factors are thought to be key downstream targets of the retinoblastoma protein (pRB) tumor suppressor. It is widely believed that E2F1, E2F2, and E2F3 can all activate cellular proliferation but that E2F1 is the specific inducer of apoptosis. Here we show that the E2f3 mutation completely suppresses both the inappropriate proliferation and the p53-dependent apoptosis arising in the Rb mutant...

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Share to Apoptosis
Share to Cell Division
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 11230146
DOI: 10.1101/gad.858801
PMCID: PMC312633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos.PMID 11230146Read ↗

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