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Article

Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.

The Journal of biological chemistry - 9 Aug 2002

Gale Andrew J, Tsavaler Alexander, Griffin John H

Abstract excerpt

The anticoagulant human plasma serine protease, activated protein C (APC), inhibits blood coagulation by specific inactivation of the coagulation cofactors factor Va (FVa) and factor VIIIa. Site-directed mutagenesis of residues in three surface loops of a positive exosite located on APC was used to identify residues that play a significant role in binding to FVa. Eighteen different residues were mutated to...

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Source

Identifiers

PMID: 12063259
DOI: 10.1074/jbc.M204363200

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.PMID 12063259Read ↗

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