Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa.

doi:10.1073/pnas.93.25.14379

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Article

Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996

Dickinson C D, Kelly C R, Ruf W

Abstract excerpt

Factor VIIa (VIIa), the serine protease that initiates the coagulation pathways, is catalytically activated upon binding to its cell surface receptor and cofactor tissue factor (TF). This study provides a comprehensive analysis of the functional surface of VIIa by alanine scanning mutagenesis of...

Topics

Binding Sites
Factor VIIa
Humans
Models, Molecular
Mutation
Protein Conformation
Recombinant Proteins
Thromboplastin

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