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Article

Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex.

The Journal of biological chemistry - 25 Jul 2003

Chen Lin, Yang Likui, Rezaie Alireza R

Abstract excerpt

Although the contribution of basic residues of exosite-1 to the catalytic function of thrombin has been studied extensively, their role in the specificity of prothrombin recognition by factor Xa in the prothrombinase complex (factor Xa, factor Va, phosphatidylcholine/phosphatidylserine vesicles, and Ca2+) has not been examined. In this study, we prepared several mutants of prethrombin-1 (prothrombin lacking Gla...

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Identifiers

PMID: 12750382
DOI: 10.1074/jbc.M302707200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex.PMID 12750382Read ↗

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Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa.Semantic proximity Read ↗

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