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Article

Contribution of factor VIII light-chain residues 2007-2016 to an activated protein C-interactive site.

Thrombosis and haemostasis - 1 Feb 2013

Takeyama Masahiro, Wakabayashi Hironao, Fay Philip J

Abstract excerpt

Although factor (F) VIIIa is inactivated by activated protein C (APC) through cleavages in the FVIII heavy chain-derived A1 (Arg(336)) and A2 subunits (Arg(562), the FVIII light chain (LC) contributes to catalysis by binding the enzyme. ELISA-based binding assays showed that FVIII and FVIII LC bound to immobilised active site-modified APC (DEGR-APC) (apparent K(d) ~270 nM and 1.0 μM, respectively). Fluid-phase...

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Identifiers

PMID: 23224054
DOI: 10.1160/TH12-08-0561
PMCID: PMC3665284

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Contribution of factor VIII light-chain residues 2007-2016 to an activated protein C-interactive site.PMID 23224054Read ↗

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