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Article

Function of the activated protein C (APC) autolysis loop in activated FVIII inactivation.

British journal of haematology - 1 Jun 2011

Cramer Thomas J, Gale Andrew J

Abstract excerpt

Activated protein C (APC) binds to its substrates activated factor V (FVa) and activated factor VIII (FVIIIa) with a basic exosite that consists of loops 37, 60, 70 and the autolysis loop. These loops have a high density of basic residues, resulting in a positive charge on the surface of APC. Many of these residues are important in the interaction of APC with FVa and FVIIIa. The current study focused on the...

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Identifiers

PMID: 21457218
DOI: 10.1111/j.1365-2141.2011.08657.x
PMCID: PMC3091999

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Function of the activated protein C (APC) autolysis loop in activated FVIII inactivation.PMID 21457218Read ↗

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