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Article

The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans.

Development (Cambridge, England) - 1 Oct 2014

Luo Shuo, Schaefer Anneliese M, Dour Scott, Nonet Michael L

Abstract excerpt

We describe the identification of zyxin as a regulator of synapse maintenance in mechanosensory neurons in C. elegans. zyx-1 mutants lacked PLM mechanosensory synapses as adult animals. However, most PLM synapses initially formed during development but were subsequently lost as the animals developed. Vertebrate zyxin regulates cytoskeletal responses to mechanical stress in culture. Our work provides in vivo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25252943
DOI: 10.1242/dev.108217
PMCID: PMC4197707

Genes

ZYX
VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans.PMID 25252943Read ↗

Zyxin: a mechanotransductor to regulate gene expression.Semantic proximity Read ↗

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Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology.Semantic proximity Read ↗

Zyxin controls migration in epithelial-mesenchymal transition by mediating actin-membrane linkages at cell-cell junctions.Semantic proximity Read ↗

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A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.Semantic proximity Read ↗

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