Article
Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations.
American journal of human genetics - 1 Jul 2002
Pankratz Nathan, Nichols William C, Uniacke Sean K, Halter Cheryl, Rudolph Alice, Shults Cliff, Conneally P Michael, Foroud Tatiana
Abstract excerpt
Parkinson disease (PD) is a common neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity, and postural instability, as well as by a clinically significant response to treatment with levodopa. Mutations in the alpha-synuclein gene have been found to result in autosomal dominant PD, and mutations in the parkin gene produce autosomal recessive juvenile-onset PD. We have studied...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.