Article
Genetic linkage studies in autosomal dominant parkinsonism: evaluation of seven candidate genes.
Annals of neurology - 1 Sept 1994
Gasser T, Wszolek Z K, Trofatter J, Ozelius L, Uitti R J, Lee C S, Gusella J, Pfeiffer R F, Calne D B, Breakefield X O
Abstract excerpt
Linkage studies were performed in three families (A, B, and C) with autosomal dominantly inherited parkinsonism affecting multiple members in three generations. Affected individuals exhibited the cardinal signs and symptoms of Parkinson's disease, with a mean age of onset of 51, 62, and 61 years...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Female
- Genes, Dominant
- Genetic Linkage
- Humans
- Lod Score
- Male
- Middle Aged
- Parkinson Disease
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Repetitive Sequences, Nucleic Acid