Article
The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype.
Molecular biology of the cell - 1 Jun 2002
Okuwaki Mitsuru, Tsujimoto Masafumi, Nagata Kyosuke
Abstract excerpt
Nucleophosmin/B23 is a nucleolar phosphoprotein. It has been shown that B23 binds to nucleic acids, digests RNA, and is localized in nucleolar granular components from which preribosomal particles are transported to cytoplasm. The intracellular localization of B23 is significantly changed during the cell cycle. Here, we have examined the cellular localization of B23 proteins and the effect of mitotic...
Topics
- Actins
- Alternative Splicing
- Amino Acid Substitution
- Animals
- Base Sequence
- Cell Nucleolus
- Chickens
- Cyclin-Dependent Kinases
- DNA Primers
- Deoxyribonuclease I
- Enhancer Elements, Genetic