Article
Conditional expression of a constitutively active aryl hydrocarbon receptor in MCF-7 human breast cancer cells.
Archives of biochemistry and biophysics - 15 Jun 2002
Köhle Christoph, Hassepass Ingo, Bock-Hennig Barbara S, Walter Bock Karl, Poellinger Lorenz, McGuire Jacqueline
Abstract excerpt
In addition to inducing transcription of a battery of target genes encoding drug-metabolizing enzymes, the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to induce antiestrogenic responses. However, the mechanisms underlying such complex biologic responses affecting growth and differentiation remain unclear. In the present study we have investigated biological effects of a...
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