Article
Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein.
Archives of biochemistry and biophysics - 1 Oct 1997
Wilson C L, Thomsen J, Hoivik D J, Wormke M T, Stanker L, Holtzapple C, Safe S H
Abstract excerpt
Several studies have reported a correlation between expression of the estrogen receptor (ER) and aryl hydrocarbon (Ah) responsiveness in human breast cancer cell lines. MDA-MB-231 cells are ER-negative and Ah-nonresponsive; however, initial studies showed that 2,3,7,8-tetrachlorodibenzo-p-dioxin...
Topics
- Amino Acid Sequence
- Aryl Hydrocarbon Receptor Nuclear Translocator
- Breast Neoplasms
- Cytochrome P-450 CYP1A1
- DNA Primers
- DNA-Binding Proteins
- Enzyme Induction
- Female
- Genetic Variation
- Humans
- Molecular Sequence Data
- Polychlorinated Dibenzodioxins
- Polymerase Chain Reaction