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Article

Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells

15 Apr 2002

Abstract excerpt

Genomic imprinting is an epigenetic mechanism that causes functional differences between paternal and maternal genomes, and plays an essential role in mammalian development. Stage-specific changes in the DNA methylation patterns of imprinted genes suggest that their imprints are erased some time during the primordial germ cell (PGC) stage, before their gametic patterns are re-established during gametogenesis...

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Share to Epigenetics and DNA Methylation
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PMID: 11934847
DOI: 10.1242/dev.129.8.1807

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