Article
Phenotypic changes and cell cycle activation in early tubulointerstitial injury of rat adriamycin nephrosis.
Pathology international - 1 Mar 2002
Shu Yujing, Hoshi Sachi, Tomari Shinsuke, Watanabe Teruo, Nagata Michio
Abstract excerpt
Tubular response, including phenotypic changes against a variety of injuries, is an initial event that promotes tubulointerstitial injuries. Using the progressive kidney disease model of rat adriamycin (ADR) nephrosis, the present study focused on the cell cycle activation and phenotypic changes that occur in the tubuli in early tubulointerstitial injury in ADR nephrosis. At 12 weeks, experimental animals...
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