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Article

Cell division and phenotypic regression of proximal tubular cells in response to uranyl acetate insult in rats.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Sept 2009

Fujigaki Yoshihide, Sakakima Masanori, Sun Yuan, Fujikura Tomoyuki, Tsuji Takayuki, Yasuda Hideo, Hishida Akira

Abstract excerpt

BACKGROUND: We examined whether dedifferentiation is necessary for cell division of proximal tubule (PT) cells after acute PT injury. METHODS: Rats were injected with a low (0.2 mg/kg) or high (4 mg/kg) dose of uranyl acetate (UA) to induce acute PT injury. Proliferating PT cells were labelled with bromodeoxyuridine (BrdU) before sacrifice. Renal tissues were examined by double labelling of BrdU and megalin,...

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Source

Identifiers

PMID: 19395729
DOI: 10.1093/ndt/gfp199

Genes

AQP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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