Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction.

The Journal of clinical investigation - 1 Jun 2002

Ichinose Fumito, Ullrich Roman, Sapirstein Adam, Jones Rosemary C, Bonventre Joseph V, Serhan Charles N, Bloch Kenneth D, Zapol Warren M

Abstract excerpt

Cytosolic phospholipase A(2) (cPLA(2)) releases arachidonic acid (AA) from phospholipids in cell membranes. To assess the role of cPLA(2) in hypoxic pulmonary vasoconstriction (HPV), we measured the increase in left lung pulmonary vascular resistance (LPVR) before and during hypoxia produced by l...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin II
Share to Cyclooxygenase Inhibitors
Share to Gas Chromatography-Mass Spectrometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Indomethacin

Share to NG-Nitroarginine Methyl Ester

Share to Phospholipases A

Share to Vasoconstriction

Source

Open in PubMed Open full text

Identifiers

PMID: 12045263
DOI: 10.1172/JCI14294
PMCID: PMC150993

Genes

PVR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12045263-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction.PMID 12045263Read ↗

Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro.Semantic proximity Read ↗

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.Semantic proximity Read ↗

CYP2J2 and EETs Protect Against Pulmonary Hypertension with Lung Ischemia-Reperfusion Injury In Vivo and In VitroSemantic proximity Read ↗

Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.Semantic proximity Read ↗

Pulmonary vascular disease related to hemodynamic stress in the pulmonary circulation.Semantic proximity Read ↗

Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j.Semantic proximity Read ↗

Resistance to endotoxic shock in phospholipase A2 receptor-deficient mice.Semantic proximity Read ↗

Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2.Semantic proximity Read ↗

Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.Semantic proximity Read ↗

TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process.Semantic proximity Read ↗

Polymerase delta interacting protein 2 sustains vascular structure and function.Semantic proximity Read ↗

Regulation of type V phospholipase A<sub>2</sub> expression and function by proinflammatory stimuliSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.