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Article

Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2.

Carcinogenesis - 1 Aug 2004

Meyer Amy M, Dwyer-Nield Lori D, Hurteau Gregory J, Keith Robert L, O'Leary Eileen, You Ming, Bonventre Joseph V, Nemenoff Raphael A, Malkinson Alvin M

Abstract excerpt

Epidemiological investigations suggest that chronic lung inflammation increases lung cancer risk. Pharmacologic and genetic evidence in mouse models indicates that lipid mediators released during pulmonary inflammation enhance lung tumor formation. Cytosolic phospholipase A2 (cPLA2) catalyzes ara...

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Source

Identifiers

PMID: 15033900
DOI: 10.1093/carcin/bgh150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15033900-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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