Article
Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro.
American journal of respiratory cell and molecular biology - 1 Mar 2011
Dudek Steven M, Muñoz Nilda M, Desai Anjali, Osan Christopher M, Meliton Angelo Y, Leff Alan R
Abstract excerpt
We examined the functional role of 14-kD secretory group V phospholipase A(2) (gVPLA(2)) on the barrier function of pulmonary endothelial cells (ECs) after LPS activation in vitro. Expression of gVPLA(2) was elicited by 20 ng/ml LPS as demonstrated by increased (1) mRNA, (2) protein content, and (3) cell surface expression of gVPLA(2) within 4 hours. The effect of LPS on EC barrier function was measured by...
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