Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.

The American journal of pathology - 1 Aug 2002

Bonner James C, Rice Annette B, Ingram Jennifer L, Moomaw Cindy R, Nyska Abraham, Bradbury Alyce, Sessoms Alisha R, Chulada Patricia C, Morgan Daniel L, Zeldin Darryl C, Langenbach Robert

Abstract excerpt

The cyclooxygenase (COX)-2 enzyme has been implicated as an important mediator of pulmonary fibrosis. In this study, the lung fibrotic responses were investigated in COX-1 or COX-2-deficient (-/-) mice following vanadium pentoxide (V(2)O(5)) exposure. Lung histology was normal in saline-instilled...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dinoprostone
Share to Cyclooxygenase 2
Share to Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoenzymes

Share to Mice, Knockout

Share to Prostaglandin-Endoperoxide Synthases

Share to Pulmonary Fibrosis

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 12163371
DOI: 10.1016/S0002-9440(10)64202-2
PMCID: PMC1850724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12163371-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.PMID 12163371Read ↗

Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis.Semantic proximity Read ↗

Genetic susceptibility to interstitial pulmonary fibrosis in mice induced by vanadium pentoxide (V2O5).Semantic proximity Read ↗

Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2.Semantic proximity Read ↗

Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner.Semantic proximity Read ↗

Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) geneSemantic proximity Read ↗

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.Semantic proximity Read ↗

Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitisSemantic proximity Read ↗

Disruption of the mouse cyclooxygenase 1 gene. Characteristics of the mutant and areas of future study.Semantic proximity Read ↗

Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.Semantic proximity Read ↗

Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent.Semantic proximity Read ↗

Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity.Semantic proximity Read ↗

Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.