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Article

TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2014

Pandit Lavannya M, Lloyd Eric E, Reynolds Julia O, Lawrence William S, Reynolds Corey, Wehrens Xander H T, Bryan Robert M

Abstract excerpt

TWIK-2 (KCNK6) is a member of the 2-pore domain (K2P) family of potassium channels, which are highly expressed in the vascular system. We tested the hypothesis that TWIK-2 deficiency leads to pulmonary hypertension. TWIK-2 knockout mice and their wildtype littermates at 8 weeks of age had similar mean right ventricular systolic pressures (24±3 and 21±3 mm Hg, respectively.) Significantly, by 20 weeks of age, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25245387
DOI: 10.1161/HYPERTENSIONAHA.114.03406
PMCID: PMC4231005

Genes

KCNK6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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