Polymorphic distribution of the ovine prion protein (PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie.

doi:10.1016/s0093-691x(02)00673-8

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Polymorphic distribution of the ovine prion protein (PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie.

Theriogenology - 15 Apr 2002

Wang Shiquan, Cockett Noelle E, Miller Janice M, Shay Tracy L, Maciulis Alma, Sutton Diane L, Foote Warren C, Holyoak Gilbert R, Evans Ronald C, Bunc Thomas D, Beever Jonathan E, Call Jay W, Taylor William D, Marshall Michael R

Abstract excerpt

The genetic sequence of the ovine prion protein (PrP) gene between codons 102 and 175 with emphasis on ovine PrP gene codons 136 and 171 was determined, and the polymorphic distribution of the ovine PrP gene in the scrapie-exposed Suffolk embryo donors and offspring from these donors that were transferred to scrapie-free recipient ewes was investigated in this study. The most common genotype was AA(136)QQ(171)...

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Polymorphic distribution of the ovine prion protein (PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie.

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