Article
Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants.
Carcinogenesis - 1 Jan 2001
Mondello C, Faravelli M, Pipitone L, Rollier A, Di Leonardo A, Giulotto E
Abstract excerpt
In search of functions involved in the regulation of gene amplification, and given the relevance of chromosome breakage in initiating the process, we analyzed the gene amplification ability of cells hypersensitive to inducers of DNA double-strand breaks and defective in cell cycle control: two human fibroblast strains derived from patients affected by ataxia telangiectasia (AT) and two hamster mutant cell lines...
Topics
- Animals
- Antimetabolites, Antineoplastic
- Aspartate Carbamoyltransferase
- Aspartic Acid
- Ataxia Telangiectasia
- Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
- Cell Line
- Cricetinae
- Cricetulus
- Dihydroorotase
- Drug Resistance, Neoplasm
- Fibroblasts
- Gene Amplification