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Article

Normal diploid human and rodent cells lack a detectable frequency of gene amplification.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990

Tlsty T D

Abstract excerpt

Gene amplification is frequently observed in tumors and transformed cell lines. This phenomenon is known to contribute to the generation of drug-resistant tumor cells and quantitation of the event is believed to have prognostic value in several types of neoplasias. To date, most studies of gene amplification have used immortalized cell lines and biopsied tumor samples. In this study I examine the amplification...

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Identifiers

PMID: 2326271
DOI: 10.1073/pnas.87.8.3132
PMCID: PMC53848

Genes

CAD
DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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