Article
Normal diploid human and rodent cells lack a detectable frequency of gene amplification.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Tlsty T D
Abstract excerpt
Gene amplification is frequently observed in tumors and transformed cell lines. This phenomenon is known to contribute to the generation of drug-resistant tumor cells and quantitation of the event is believed to have prognostic value in several types of neoplasias. To date, most studies of gene a...
Topics
- Animals
- Antineoplastic Agents
- Aspartic Acid
- Cell Division
- Cells, Cultured
- Diploidy
- Drug Resistance
- Fibroblasts
- Gene Amplification
- Humans
- Methotrexate
- Phenotype
- Phosphonoacetic Acid
- Rats
- Reference Values
- Species Specificity
- Tumor Cells, Cultured