Article
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2002
Bassing Craig H, Chua Katrin F, Sekiguchi JoAnn, Suh Heikyung, Whitlow Scott R, Fleming James C, Monroe Brianna C, Ciccone David N, Yan Catherine, Vlasakova Katerina, Livingston David M, Ferguson David O, Scully Ralph, Alt Frederick W
Abstract excerpt
In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form gamma-H2AX) in megabase chromatin domains flanking sites of DNA damage. To investigate the role of H2AX in mammalian cells, we generated H2AX-deficient (H2AX(Delta)/Delta) mouse embryonic stem (ES) cells. H2AX(Delta)/Delta ES cells are viable. However, they are highly sensitive to ionizing...
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