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Article

Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2011

Revet Ingrid, Feeney Luzviminda, Bruguera Stephanie, Wilson Wade, Dong Tiffany K, Oh Dennis H, Dankort David, Cleaver James E

Abstract excerpt

The phosphorylation of H2Ax on its S139 site, γH2Ax, is important during DNA double-strand repair and is considered necessary for assembly of repair complexes, but its functional role after other kinds of DNA damage is less clear. We have measured the survival of isogenic mouse cell lines with the H2Ax gene knocked out, and replaced with wild-type or mutant (S139A) H2Ax genes, exposed to a range of agents with...

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PMID: 21555580
DOI: 10.1073/pnas.1105866108
PMCID: PMC3102364

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Source receipt: pubmed, retrieved 7 Sept 2026.

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