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Article

Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals.

The Journal of cell biology - 16 Jul 2007

Kim Jung-Ae, Kruhlak Michael, Dotiwala Farokh, Nussenzweig André, Haber James E

Abstract excerpt

Double-strand break (DSB) damage in yeast and mammalian cells induces the rapid ATM (ataxia telangiectasia mutated)/ATR (ataxia telangiectasia and Rad3 related)-dependent phosphorylation of histone H2AX (gamma-H2AX). In budding yeast, a single endonuclease-induced DSB triggers gamma-H2AX modifica...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17635934
DOI: 10.1083/jcb.200612031
PMCID: PMC2064441

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17635934-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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