Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing Radiation

15 Dec 2022

Abstract excerpt

People exposed to ionizing radiation (IR) both for diagnostic and therapeutic purposes is constantly increasing. Since the use of IR involves a risk of harmful effects, such as the DNA DSB induction, an accurate determination of this induced DNA damage and a correct evaluation of the risk-benefit ratio in the clinical field are of key relevance. γH2AX (the phosphorylated form of the histone variant H2AX) is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms
Share to Radiation Therapy and Dosimetry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36551689
DOI: 10.3390/cancers14246204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing RadiationPMID 36551689Read ↗

Genome Instability and γH2AX.Semantic proximity Read ↗

H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer TherapySemantic proximity Read ↗

What Does the History of Research on the Repair of DNA Double-Strand Breaks Tell Us?—A Comprehensive Review of Human RadiosensitivitySemantic proximity Read ↗

γ-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skinSemantic proximity Read ↗

DNA double-strand break repair capacity and normal tissue toxicity induced by radiotherapySemantic proximity Read ↗

Key molecular DNA damage responses of human cells to radiationSemantic proximity Read ↗

Ionizing Radiation and Human Health: Reviewing Models of Exposure and Mechanisms of Cellular Damage. An Epigenetic PerspectiveSemantic proximity Read ↗

A historical reflection on our understanding of radiation-induced DNA double strand break repair in somatic mammalian cells; interfacing the past with the presentSemantic proximity Read ↗

Radiation induced DNA damage and damage repair in human tumor and fibroblast cell lines assessed by histone H2AX phosphorylationSemantic proximity Read ↗

γH2AX as a marker of DNA double strand breaks and genomic instability in human population studiesSemantic proximity Read ↗

Activation of DNA damage response signaling in mammalian cells by ionizing radiationSemantic proximity Read ↗

Validation of a flow cytometry‐based detection of γ‐H2AX, to measure DNA damage for clinical applicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.