Article
Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice.
The Journal of biological chemistry - 9 Aug 2002
Matsumoto Hiromichi, Ma Wen-Ge, Daikoku Takiko, Zhao Xhume, Paria Bibhash C, Das Sanjoy K, Trzaskos James M, Dey Sudhansu K
Abstract excerpt
Increased vascular permeability and angiogenesis at the site of blastocyst apposition in the uterus are two hallmarks of the implantation process. The present investigation shows that although the proangiogenic vascular endothelial growth factor (VEGF) and its receptor, Flk-1, are primarily important for uterine vascular permeability and angiogenesis prior to and during the attachment phase of the implantation...
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