Article

Uterine stromal but not epithelial PTGS2 is critical for murine pregnancy success

2024-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Use of non-steroidal anti-inflammatory drugs that target prostaglandin synthase (PTGS) enzymes have been implicated in miscarriage. Further, PTGS2-derived prostaglandins are reduced in the endometrium of patients with a history of implantation failure. However, in the mouse model of pregnancy, peri-implantation PTGS2 function is controversial. Some studies suggest that Ptgs2 -/- mice display d...

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Literature Corpus work: 59d00625-3000-5de0-af96-f86e7c5008de
DOI: 10.1101/2024.10.24.620133

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