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Article

Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.

The Journal of biological chemistry - 24 Nov 2000

Scherle P A, Ma W, Lim H, Dey S K, Trzaskos J M

Abstract excerpt

The infertility phenotype of cyclooxygenase-2 (Cox-2)-deficient female mice establishes the important role of Cox-2 in pregnancy. Cox-2 deficiency results in defective ovulation, fertilization, implantation, and decidualization; the latter of which can be restored in part by the prostacyclin analog carbaprostacyclin. Uterine Cox-2 expression during early pregnancy shows distinct localization and kinetics in the...

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PMID: 10969080
DOI: 10.1074/jbc.M006168200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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