Article
Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.
The Journal of biological chemistry - 24 Nov 2000
Scherle P A, Ma W, Lim H, Dey S K, Trzaskos J M
Abstract excerpt
The infertility phenotype of cyclooxygenase-2 (Cox-2)-deficient female mice establishes the important role of Cox-2 in pregnancy. Cox-2 deficiency results in defective ovulation, fertilization, implantation, and decidualization; the latter of which can be restored in part by the prostacyclin analog carbaprostacyclin. Uterine Cox-2 expression during early pregnancy shows distinct localization and kinetics in the...
Topics
- Animals
- Cyclooxygenase 2
- Decidua
- Enzyme Activation
- Enzyme Inhibitors
- Female
- Imidazoles
- Isoenzymes
- MAP Kinase Kinase 1
- MAP Kinase Kinase 2
- Mice
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Oils