Article
Identifying critical non-catalytic residues that modulate protein kinase A activity.
PloS one - 1 Jan 2009
Kennedy Eileen J, Yang Jie, Pillus Lorraine, Taylor Susan S, Ghosh Gourisankar
Abstract excerpt
BACKGROUND: Distal interactions between discrete elements of an enzyme are critical for communication and ultimately for regulation. However, identifying the components of such interactions has remained elusive due to the delicate nature of these contacts. Protein kinases are a prime example of an enzyme with multiple regulatory sites that are spatially separate, yet communicate extensively for tight regulation...
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