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Article

Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding.

The Journal of biological chemistry - 24 Feb 2006

Montalibet Jacqueline, Skorey Kathryn, McKay Dan, Scapin Giovanna, Asante-Appiah Ernest, Kennedy Brian P

Abstract excerpt

Regions of protein-tyrosine phosphatase (PTP) 1B that are distant from the active site yet affect inhibitor binding were identified by a novel library screen. This screen was based on the observation that expression of v-Src in yeast leads to lethality, which can be rescued by the coexpression of PTP1B. However, this rescue is lost when yeast are grown in the presence of PTP1B inhibitors. To identify regions of...

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PMID: 16332678
DOI: 10.1074/jbc.M511546200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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