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Article

Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants.

Journal of medicinal chemistry - 13 Jan 2005

Breitenlechner Christine B, Friebe Walter-Gunar, Brunet Emmanuel, Werner Guido, Graul Klaus, Thomas Ulrike, Künkele Klaus-Peter, Schäfer Wolfgang, Gassel Michael, Bossemeyer Dirk, Huber Robert, Engh Richard A, Masjost Birgit

Abstract excerpt

Protein kinase B (PKB)-selective inhibitors were designed, synthesized, and cocrystallized using the AGC kinase family protein kinase A (PKA, often called cAMP-dependent protein kinase); PKA has been used as a surrogate for other members of this family and indeed for protein kinases in general. T...

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Identifiers

PMID: 15634010
DOI: 10.1021/jm049701n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15634010-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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