Article
Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants.
Journal of medicinal chemistry - 13 Jan 2005
Breitenlechner Christine B, Friebe Walter-Gunar, Brunet Emmanuel, Werner Guido, Graul Klaus, Thomas Ulrike, Künkele Klaus-Peter, Schäfer Wolfgang, Gassel Michael, Bossemeyer Dirk, Huber Robert, Engh Richard A, Masjost Birgit
Abstract excerpt
Protein kinase B (PKB)-selective inhibitors were designed, synthesized, and cocrystallized using the AGC kinase family protein kinase A (PKA, often called cAMP-dependent protein kinase); PKA has been used as a surrogate for other members of this family and indeed for protein kinases in general. The high homology between PKA and PKB includes very similar ATP binding sites and hence similar binding pockets for...
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