Article
Effects of adenine-nucleotides on the sequence-specificity of origin recognition complex-binding to DNA.
Biological & pharmaceutical bulletin - 1 May 2002
Takenaka Hitomi, Takahashi Naoko, Lee Jong-Ryul, Makise Masaki, Yamaguchi Yoshihiro, Tsuchiya Tomofusa, Mizushima Tohru
Abstract excerpt
We examined effects of adenine-nucleotides on the sequence-specificity of origin recognition complex (ORC)-binding to DNA, using a gel electrophoretic mobility shift assay. The sequence-specific DNA binding of ORC was observed in the presence of ATP or ATP-gamma-S but not in the presence of adenosine 5'-diphosphate (ADP) or in the absence of any adenine-nucleotides. In contrast, the sequence-independent DNA...
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