Article
Mutations in the mitochondrial DNA D-Loop region occur frequently in adenocarcinoma in Barrett's esophagus.
Oncogene - 23 May 2002
Miyazono Futoshi, Schneider Paul M, Metzger Ralf, Warnecke-Eberz Ute, Baldus Stephan E, Dienes Hans P, Aikou Takashi, Hoelscher Arnulf H
Abstract excerpt
Mitochondrial DNA (mtDNA) is known for high mutation rates caused by lack of protective histones, inefficient DNA repair systems, and continuous exposure to mutagenic effects of oxygen radicals. We examined the frequency of mutations in the mtDNA D-Loop region in 20 patients with Barrett's carcinoma and associated Barrett's epithelium by automated DNA sequencing. Mutations were detected in eight of 20 (40%)...
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