Article
Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence.
BMC cancer - 19 Jul 2016
O'Farrell N J, Feighery R, Picardo S L, Lynam-Lennon N, Biniecka M, McGarrigle S A, Phelan J J, MacCarthy F, O'Toole D, Fox E J, Ravi N, Reynolds J V, O'Sullivan J
Abstract excerpt
BACKGROUND: Barrett's esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett's esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis of this disease sequence is poorly understood. Mitochondria are highly susceptible to mutations due to high levels of reactive oxygen species (ROS) coupled with low levels of DNA repair. The timing...
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