Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome.

The EMBO journal - 1 Jun 1999

Yie J, Merika M, Munshi N, Chen G, Thanos D

Abstract excerpt

Transcriptional activation of the virus inducible enhancer of the human interferon-beta (IFN-beta) gene in response to virus infection requires the assembly of an enhanceosome, consisting of the transcriptional activators NF-kappaB, ATF-2/c-Jun, IRFs and the architectural protein of the mammalian high mobility group I(Y) [HMG I(Y)]. Here, we demonstrate that the first step in enhanceosome assembly, i.e. HMG...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 2
Share to Cyclic AMP Response Element-Binding Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Footprinting

Share to High Mobility Group Proteins

Share to Interferon-beta

Share to Interferon Regulatory Factor-1

Share to Proto-Oncogene Proteins c-jun

Share to Repetitive Sequences, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 10357819
DOI: 10.1093/emboj/18.11.3074
PMCID: PMC1171389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome.PMID 10357819Read ↗

Coordination of a transcriptional switch by HMGI(Y) acetylation.Semantic proximity Read ↗

Assembly of a Functional Beta Interferon Enhanceosome Is Dependent on ATF-2–c-jun Heterodimer OrientationSemantic proximity Read ↗

Mechanism for specificity by HMG-1 in enhanceosome assembly.Semantic proximity Read ↗

A role for the architectural transcription factors HMGI(Y) in cytokine gene transcription in T cells.Semantic proximity Read ↗

The DNA architectural protein HMGB1 displays two distinct modes of action that promote enhanceosome assembly.Semantic proximity Read ↗

HMGB1: The jack‐of‐all‐trades protein is a master DNA repair mechanicSemantic proximity Read ↗

Epigenetic and transcriptional control of interferon-βSemantic proximity Read ↗

The Role of High-Mobility Group I(Y) Proteins in Expression of IL-2 and T Cell ProliferationSemantic proximity Read ↗

Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responsesSemantic proximity Read ↗

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In VivoSemantic proximity Read ↗

NF-kappaB mediated transcriptional activation is enhanced by the architectural factor HMGI-C.Semantic proximity Read ↗

The S box of major histocompatibility complex class II promoters is a key determinant for recruitment of the transcriptional co-activator CIITA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.