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Article

HMGB1: a double-edged sword and therapeutic target in the female reproductive system

18 Aug 2023

Abstract excerpt

HMGB1 that belongs to the High Mobility Group-box superfamily, is a nonhistone chromatin associated transcription factor. It is present in the nucleus of eukaryotes and can be actively secreted or passively released by kinds of cells. HMGB1 is important for maintaining DNA structure by binding to DNA and histones, protecting it from damage. It also regulates the interaction between histones and DNA, affecting...

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PMID: 37691930
DOI: 10.3389/fimmu.2023.1238785

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