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Article

Aberrant allele-switch imprinting of a novel IGF1R intragenic antisense non-coding RNA in breast cancers.

European journal of cancer (Oxford, England : 1990) - 1 Jan 2015

Kang Lihua, Sun Jingnan, Wen Xue, Cui Jiuwei, Wang Guanjun, Hoffman Andrew R, Hu Ji-Fan, Li Wei

Abstract excerpt

The insulin-like growth factor type I receptor (IGF1R) is frequently dysregulated in breast cancers, yet the molecular mechanisms are unknown. A novel intragenic long non-coding RNA (lncRNA) IRAIN within the IGF1R locus has been recently identified in haematopoietic malignancies using RNA-guided chromatin conformation capture (R3C). In breast cancer tissues, we found that IRAIN lncRNA was transcribed from an...

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Share to DNA Methylation
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, IGF Type 1

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Antisense

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Source

Identifiers

PMID: 25465188
DOI: 10.1016/j.ejca.2014.10.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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