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Article

Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.

Human molecular genetics - 15 Apr 2007

Valleley Elizabeth M, Cordery Sarah F, Bonthron David T

Abstract excerpt

The tumour suppressor gene ZAC/PLAGL1 is widely expressed in many human tissues during fetal development and throughout life. It encodes a DNA-binding protein which shares with p53 the ability to regulate apoptosis and cell cycle arrest concurrently. Owing to its anti-proliferative properties, down-regulation or loss of ZAC is believed to deregulate cell growth, and loss of expression has been observed in a...

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Source

Identifiers

PMID: 17341487
DOI: 10.1093/hmg/ddm041

Genes

PLAGL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.PMID 17341487Read ↗

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LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functionsSemantic proximity Read ↗

The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetesSemantic proximity Read ↗

Zac1 Regulates an Imprinted Gene Network Critically Involved in the Control of Embryonic GrowthSemantic proximity Read ↗

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Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop.Semantic proximity Read ↗

LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.Semantic proximity Read ↗

The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice.Semantic proximity Read ↗

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